04.06.2008. (Wednesday)

9.00 - 13.00 Morning session

Chair: R. H. Smith

9.00 – 9.30 – Robert Smith “Racemic heterochiral a ssemblies": A novel aspect of chirality: biological implications”

9.30 – 10.00 – Jaime Kapitulnik "The blood- brain barrier: its role in brain disposition and toxicity of xenobiotics"

10.00 – 10.30 – Gabrielle Hawksworth “Hepatic and renal drug transporters: drug drug interactions and drug-induced toxicity”

10.30 – 11.00 – Momir Mikov “Xenobiotic metabolism by gut flora understanding is crucial for metabolic profiling”

11.00 – 11.30 – coffee break, posters mounting

Chair: G. Hawksworth

11.30 – 12.00 – David Bell " A robust examination of the developmental reproductive toxicity of TCDD”

12.00 – 12.30 – Mumtaz Iscan "The role of GST polymorphysms on the response to therapy and survival in lung cancer patients”

13.00 - 14.00 Lunch

14.00 – 15.00 Poster session

15.00 – 17.00 Afternoon session

Chair: S. Yanev

15.00 – 15.20 – Paraskevi Papaioannidou “ E strogenic effect of DDT on 2D:4D ratio in middle aged people in Greece”

15.20 – 15.40 – Dragan Joksovi c “ Toxic liver damage in acute poisoning by organophosphorus insecticides ”

15.40 – 16.00 – Violeta Stanimirovic “ Regulatory guidelines related to drug metabolismas predominant imperative for qa in drug discovery ”

16.00 – 16.20 – coffee break

Chair: K. Ðakovic-Švajcer

16.20 – 16.40 – Vesna Matovic “ Cadmium-induced alterations in fenton metals (iron and copper) and lipid peroxidation in the kidney of male mice ”

16.20 – 17.00 – Isidora Samojlik “ Herb-drug interaction: the influence of essential oil of caraway on pharmacokinetic of paracetamol ”

Picnic after afternoon session

05.06.2008. (Thursday)

9.00 – 13.00 Morning session

Chair: A. Boobis

9.00 – 9.30 – Alan Boobis "Effects of combined chemical exposure: Proteomic approaches"

9.30 – 10.00 – Olavi Pelkonen “Local kinetics of xenobiotics: importance of metabolic competence in in vitro toxicity testing”

10.30 – 11.00 – coffee break

Chair: D. Bell

11.00 – 11.30 – Achilles Benakis “The regulation and quality control of drugs during the process of their development”

11.30 – 12.00 – Katalin Jemnitz “ Sandwich culture of primary hepatocytes: A useful model for studying ABC transporter activities”

12.00 – 12.20 – Milan Stanulovic “Biotechnologiically derived medicines after the patent expiration”

12.20 – 12.50 – Kornelia Ðakovic Svajcer “ The pharmacokinetic changes in the elderly”

13.00 - 14.00 Lunch

14.00 – 15.00 Poster session

15.00 – 17.00 Afternoon session

Chair: M. Mikov

15.00 – 15.30 – Sebastijan Kujundzic „Not Only Data but Answers - Getting Typical ADME Parameters Directly from Your LCMS Software and Identification of Drug Metabolites“

15.30 – 16.00 – coffee break

16.00 – 18.00 – Workshop „Practical demonstration of Rapid Resolution LC system with triple quadrupol MS detection in ADME“ Departure to Department of Chemistry, Faculty of Sciences, University of Novi Sad;, coordinator: Sebastijan Kujundzic

06.06.2008. (Friday)

9.00 – 13.00 Morning session

Chair and young scientists award committee: O. Pelkonen, A. Benakis, M. Iscan

9.00 – 9.20 – Vukosava Milic Djordjevic „Protective effect of fullerenol C 60 (OH) 24 on lipid peroxidation of rat tissues treated with doxorubicin“

9.20 – 9.40 – Aleksandar Raskovic “ Pharmacological effects of diclofenac and acetaminophen in mice ”

9.40 – 10.00 – Daniela Ivanova “ Xanthate metabolism by different monooxygenses and reactive oxygen species ”

10.00 – 10.20 – Vesna Tepavcevic “ Characterisation and dissolution properties of soy isoflavones from commercial capsule preparation ”

10.20 – 10.40 – Bruno Velescu “A spects of the evaluation bioequivalence (be) of long-life drugs with active metabolites ”

10.40 – 11.10 – coffee break

11.10 – 11.30 – Biljana Bozin “ The inhibition of monoamine oxidase (MAO) by wild and cultivated garlic (Allium sp., sect. Allium) species exreacts ”

11.30 – 11.50 – Ahmet Oguz ADA “ The association between cyp1a1 (ile462val) polymorphism and survival in patients with advanced nonsmall cell lung carcinoma ”

11.50 – 12.10 – Marijana Curcic Jovanovic “ Average intake of dioxins and polychlorinated biphenyls among adult population in Serbia ”

12.10 – 13.00 – Young scientists award announcement

13.00 - 14.00 – lunch

14.00 – Closing ceremony

 Poster Presentations

01. INFLUENCE OF P ROBIOTIC PRE-TREATMENT ON THE SYSTEMIC ABSORPTION OF THE SEMISYNTHETIC BILE ACID, MKC, IN HEALTHY AND DIABETIC RATS. Hani Al-Salami, Grant Butt, J Paul Fawcett, Ian Tucker, Momir Mikov

02. PROBIOTIC PRE-TREATMENT REDUCES GLICLAZIDE PERMEATION ( EX VIVO ) IN HEALTHY RATS BUT INCREASES IT IN DIABETIC RATS TO THE LEVEL SEEN IN UNTREATED HEALTHY RATS. Hani Al-Salami, Grant Butt, J Paul Fawcett, Ian Tucker, Svetlana Golocorbin-Kon, Aleksandar Raskovic, Momir Mikov

03. GLICLAZIDE REDUCES MKC PERMEATION THROUGH THE ILEAL MUCOSA ( EX VIVO ) IN HEALTHY RATS BUT HAS NO EFFECT IN DIABETIC RATS. Hani Al-Salami, Grant Butt, J Paul Fawcett, Ian Tucker, Momir Mikov

04. EFFECT OF THE HYDROPHOBIC-HYDROPHYLLIC BALANCE OF BILE ACIDS ON SOLUBI­LIZATION OF RESVERATROL. M. Atanackovic, M. Poša, V. Krstonošic, J. Cvejic, M. Mikov, J. Popovic, Lj. Gojkovic-Bukarica

05. MAY CHRONIC TETRAHYDROCANNABINOID USAGE LED TO HEPATOTOXICITY?. Aysenur Atay, Mehmet H. Koseoglu, Baris Karadas, Ozgur Aslan, Koksal Deveci, Serap Cuhadar, Ahenk Paksoy

06. PLANTAGO LANCEOLATA L. AS A PROMISING NATURAL ANTIOXIDANT AND ANTIINFLAMMA­TORY AGENT. I. Beara, E. Jovin , B. Bozin, K. Balog, N. Mimica-Dukic, G. Anackov

07. THE IMPORTANCE AND A DANCE OF GUT MICROFLORA IN METABOLISM OF VERAPA­MIL. Gordana Bojic, Mikov Momir, Abramovic Borislav, Golocorbin Kohn Svetlana

08. EFFICACY OF DOMESTIC COMMERCIAL HYPERICUM PERFORATUM PREPARATION ON MODIFIED TAIL SUSPENSION TEST IN MICE. Z. Bukumiric, V. Jakovljevic, R. Mitic, V. Janjic, S. Stevic, Z. Stanojevic, S. Vukmirovic , A. Stolic, D. Bogojevic

09. EFFICACY OF STEVIOSIDE AND PRODUCTS CONTAINING BARLEY AND BARM WITH CHROMIUM IN LABORATORY ANIMALS. V. Cekic, V. Vasovic, V. Jakovljevic, D. Laloševic, S. Vukmirovic, A. Raškovic, B. Milijaševic

10. EFFICACY OF BARLEY FERMENTATION PRODUCTS AND BARM WITH CHROMIUM IN MICE WITH EXPERIMENTALY INDUCED HYPERGLYCEMIA. V. Cekic, V. Vasovic, V. Jakovljevic, D. Laloševic, S. Vukmirovic, Z. Tomic, M. Mikov

11. SERUM B 12 AND FOLATE LEVELS IN PSYCHIATRIC PATIENTS TREATED BY LITHIUM. Serap Cuhadar, Aysenur Atay, Mehmet H. Koseoglu, Ahenk Paksoy, Koksal Deveci, Baris Karadas, Özgür Aslan

12. ANTIMICROBIAL DRUGS IN VETERINARY MEDICINE - RISKS AND BENEFITS. Vitomir Cupic, Arturo Anadón , Silva Dobric, Silvestra Kobal

13. TESTOSTERONE AND THE MYOCARDIAL CELL: ULTRASTRUCTURAL OBSERVATIONS IN THE ADULT AND AGED RAT. M. Dermentzopoulou-Theodoridou, T. Papamitsou, E. Kotanidou., A. Kotouza, D. Barlagiannis, A. Manthos

14. ULTRASTRUCTURAL ALTERATIONS IN THE PARENCHYMAL LIVER CELL OF AGED RATS AFTER ANDROGEN TREATMENT. M. Dermentzopoulou-Theodoridou, T. Papamitsou , E. Kotanidou, A. Kotouza, D. Barlagiannis, A. Manthos

15. PHARMACOKINETICS OF ENROFLOXACIN IN JAPANESE QUAILS. D.J. Dimitrova, T. Dinev, A.G. Gentchev, S.G. Yanev, B.T. Pandova, L.D. Lashev

16. DETECTION OF DIAZEPAM IN HUMAN HAIR BY HPLC-PDA METHOD. S. Djordjevic, V. Kilibarda, D. Jovanovic, Lj. Zamurovic, M. Davidovic, Dj. Curcic

17. TOLERABILITY AND TOXICOLOGICAL PROFILE OF THE LIPIDOSTEROLIC EXTRACT OF SERENOA REPENS IN TWO DOSAGE REGIMENS. N. Duborija-Kovacevic, V. Jakovljevic, A. Sabo, Z. Tomic, A. Raskovic

18. EFFICACY OF VARIOUS FEED ADDITIVES AGAINST THE ADVERSE EFFECTS OF T-2 TOXIN IN RATS. Vesna Jacevic, Aleksandra Bocarov-Stancic, Snežana Ðordevic, Radmila Resanovic, Miodrag Lazarevic, Ana Vukajlovic, Dubravko Bokonjic

19. SPONTANEOUS REPORTING OF ADVERSE DRUG REACTIONS AT A DEPARTMENT OF INTERNAL MEDICINE. Zorica Jovic, Vidojko Djordjevic, Karin Vasic, Snezana Cekic

20. MARRUBIUM VULGARE L. FROM VOJVODINA AS A SOURCE OF BIOLOGICALY ACTIVE COMPOUNDS. E. Jovin , A. Toth, I. Beara, K. Balog, D. Orcic, N. Mimica-Dukic

21. EFFECTS OF VALPROIC ACID AND TOPIRAMATE THERAPY ON SERUM LEPTIN LEVELS. Mehmet H. Koseoglu, Aysenur Atay, Tugba Aydin, Irem Fatma Asan, Yasar Zorlu, Koksal Deveci, Baris Karadas, Serap Cuhadar

22. EFFECTS OF VALPROIC ACID AND TOPIRAMATE TREATMENT ON TOTAL ANTIOXIDANT CAPACITY. Mehmet H. Koseoglu, Aysenur Atay, Tugba Aydin, Irem Fatma Asan, Yasar Zorlu, Ahenk Paksoy, Baris Karadas, Serap Cuhadar, Koksal Deveci

23. INFLUENCE OF 12-MONO-KETO-CHOLIC ACID AND OPIOIDS ON RESPIRATORY FUNCTION IN RATS. Ivan Kuhajda, Mihalj Poša, Momir Mikov, Vida Jakovljevic, Vesna Ivetic

24. MODULATION OF ANALGESIC ACTIVITY OF MORPHINE AND TRAMADOL AFFECTED BY 12 - MONOKETOCHOLIC ACID. Ivan Kuhajda, Mihalj Poša, Momir Mikov, Vida Jakovljevic, Vesna Ivetic

25. CHANGES IN LAMOTRIGINE PLASMA CONCENTRATIONS IN MONOTHERAPY AND POLYTHERAPY WITH VALPROATE IN PATIENTS WITH EPILEPSY. M. Lalic, J. Cvejic, J. Popovic, K. Bozic

26. TUNEL-POSITIVE CELLS IN LIVER AND KIDNEYS OF ADULT MALE FISCHER 344 RATS 24 HOURS AFTER ACETAMINOPHEN OVERDOSE ADMINISTRATION: A COM­PARATIVE STUDY. Stella Makri-Patsala, Theodora Papamitsou, Christos Papanastasiou, Alexandros Toskas, Phaedra Eleft­heriou, Eleni Rekka

27. MEDICINES USED IN TOXICOLOGY LIKE ANTIDOTES WHICH ARE APPROVED FOR USE IN SERBIA. Ivana Mihajlovic

28. EFFECT OF HERBICIDE CONTAINING 2,4-DICHLORO PHENOXYACETIC ACID (2,4-D) DIMETHYLAMINE ON LIVER FUNCTIONS AND URINARY THIOETHERS EXCRETION. Ivan Mikov, Jovanka Kolarovic, Aleksandra Mikov, Vida Jakovljevic, Nikola Torbica, Momir Mikov

29. STATISTICAL POWER FUNCTION IN DETERMINATION OF DICLOFENAC RELATIVE BIOAVAILABILITY. J. Popovic, A. Sabo, M. Mikov, V. Jakovljevic

30. EFFECTS OF VARIOUS DRUGS ON OXIDATIVE STRESS IN LIVER CAUSED WITH ACUTE ALCOHOLISM. Mira Popovic, Snezana Janicijevic-Hudomal, Biljana Kaurinovic, Julijana Rasic, Svetlana Trivic

31. ANTIOXIDANT EFFECT OF SOME DRUGS ON ETHANOL-INDUCED ULCER. Mira Popovic, Snezana Janicijevic-Hudomal, Biljana Kaurinovic, Julijana Rasic, Svetlana Trivic

32. RED BLOOD CELL OSMOTIC RESISTANCE AND HEMOLYTIC POTENTIAL OF CHOLIC, DEOXYCHOLIC, CHENODEOXYCHOLIC ADCIS AND ITS KETO DERIVATIVES. Mihalj Poša, Slavko Kevrešan, Momir Mikov, Ksenija Kuhajda

33. DETERMINATION OF BUSULFAN IN SERUM BY GAS CHROMATOGRAPHY-MASS SPEC­TROMETRY. Dragana Rancic

34. DETERMINATION OF SUMATRIPTAN IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY - ELECTROSPRAY IONIZATION-MASS SPECTROMETRY (ESI-HPLC/MS) METHOD. D. Rancic, S.Djordjevic, D.Jovanovic

35. THE INFLUENCE OF SIMVASTATIN IN RATS MANDIBLE AND FEMUR BONE MASS UNDER FREUDS-ADJUVANT ARTHRITIS. N. Seferos, S. Petsaros, L. Petrokokkinos, A. Sideris, A. Pantopoulou, A. Pitsikali, A. Kotsiou, J. Vovou, C. Tesseromatis

36. TREATMENT OF MULTIPLE SCLEROSIS WITH BETAFERON: FIRST EXPERIENCE FROM TUZLA , BOSNIA AND HERZEGOVINA. Osman Sinanovic, Mirjana Vidovic, Aldina Ahmetagic, Selma Sinanovic, Adnan Burina

37. DETERMINATION OF FLUKONAZOLE IN HUMAN SERUM BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) – UV DETECTION METHOD. A. Spasic, B Ciric

38. THE EFFECT AND CORRELATION ASPIRIN AND TICLOPIDINE ADMINISTERED ALONE AND IN COMBINATION ON BIOCHEMICAL VARIABLES IN RATS. Z . Stanojevi c, R . Mitic , Z . Bukumiri c, S . Stevic , S . Smiljic , M . Misulic , M . Miletic

39. RELIABLE MICROBIOLOGICAL METHOD IN THE INVESTIGATION OF GUT MICRO­FLORA - MICE MODEL. Ljiljana Suvajdžic, Isidora Samojlik

40. INFLUENCE OF DICLOFENAK ON LIVER FUNCTION OF RATS. Z. Tomic, B. Milija ševic , A. Sabo, V. Jakovljevi c, V. Vasovic

41. CYTOSTATIC EFFECT OF SOME DITHIOCARBONIC ACID DERIVATIVES (XANTHATES) ON DIFFERENT TUMOR CELL LINES. M. Topalov, G. Momekov, S. Yanev

42. EFFECT OF LAMOTRIGINE ON CARBAMAZEPINE ELIMINATION IN EPILEPTIC PATIENTS – A POPULATION PHARMACOKINETIC STUDY. Katarina Vucicevic, Branislava Miljkovic , Milena Pokrajac, Iztok Grabnar

43. RABBIT MODEL IN OPTIMISING WARFARIN THERAPY. S. Vukmirovic, J. Popovic, V. Jakovljevic, A. Sabo, V. Vasovic, Z. Bukumiric, V. Djordjevic Milic, B. Srdjenovic

44. HYPOLIPIDEMIC EFFECTS OF SYNTHETIC SODIUM-MONOKETOCHOLATE IN DIABETIC AND HEALTHY RATS. S. Kojic-Damjanov, M. Djeric, M. Mikov, A. Raskovic, K. Kuhajda, S Kevresan

45. EFFECTS OF APPLICATION INHALED CORTICOSTEROIDS IN PREVENTION OF AS THM A ON CHILDREN IN FIRST AND SECOND YEAR OF LIFE. Milica Martinovic

46. PHARMACOLOGICAL PROPERTIES OF HOP EXTRACTS. Nebojsa Stilinovic, Aleksandar Raskovic, Vida Jakovljevic, Ana Sabo, Velibor Vasovic

47. SAFETY AND EFFICACY OF BUDESONIDE AND FLUTICASONE PROPIONATE IN PEDIATRIC PATIENTS WITH ASTHMA. V. Dumitrascu, Anca Alexandra Matusz, Daliborca Cristina Vlad

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